Technical FAQ & Knowledge Base
Common questions regarding architecture, compliance, and pipeline capabilities. Designed for Academic Administrators and Lead Investigators evaluating platform adoption.
Security, Compliance & Deployment
How does NeuroSimplicity ensure data residency compliance (GDPR/HIPAA) for institutional research?
We utilize a strictly On-Premises / Private Cloud deployment model. The Imaging Suite is deployed directly behind your institution's firewall. Raw imaging data is processed locally and never leaves your secure infrastructure. This ensures that you retain full data sovereignty and simplifies IRB compliance by eliminating third-party data transfers.
Does the platform require internet access to function?
No. Once installed, the core analysis pipelines, atlas libraries, and registration engines run entirely offline. This "air-gapped" capability is a core feature designed specifically for secure government and high-compliance laboratory environments.
Automation & Reproducibility
How do you handle inter-observer variability in longitudinal studies?
We eliminate it completely. Our platform uses Totally Automated Pipelines for segmentation and registration. Unlike manual tracing or semi-automated tools, our algorithms apply the exact same mathematical rigor to every dataset. This guarantees 100% reproducibility across different operators, sites, and timepoints.
Can the pipeline handle artifacts without manual intervention?
Yes. Our pre-processing engine includes automated artifact correction, intensity normalization, and bias field correction. The system flags data that falls below quality assurance (QA) thresholds, allowing researchers to focus on analysis rather than cleaning data pixel-by-pixel.
High-Throughput & Big Data
We generate terabytes of Light Sheet Microscopy data. Can this platform handle that volume?
Absolutely. NeuroSimplicity was architected specifically for Large Data Scales. Our engine utilizes parallelized processing and optimized memory management to handle terabyte-scale inputs efficiently. We support batch processing of hundreds of samples simultaneously, removing the bottleneck often found in legacy desktop software.
Scientific Capabilities
Is the platform limited to a single modality?
No. The Imaging Suite is Cross-Modal by design. We support the registration and analysis of data from MRI, CT, and Light Sheet Microscopy (LSM) within a unified coordinate framework. This allows for unprecedented Multi-Sample Comparison across different imaging techniques.
Can we compare our results against standard atlases?
Yes. Atlas mapping is core to our functionality. The system automatically registers your experimental data to standard reference atlases (e.g., Allen Brain Atlas), providing immediate, region-specific quantification without manual segmentation.
Standard atlases don't always reflect our specific phenotypes. Can we create custom templates from our own data?
Yes. This is a critical feature for investigating novel phenotypes or developmental stages. The Imaging Suite allows you to generate Custom Population-Specific Atlases directly from your input cohorts (e.g., creating a dedicated "Mutant" vs. "Control" template). This data-driven approach creates a mathematically optimal average of your specific group, ensuring that your registration targets faithfully represent the anatomy of your study population rather than forcing them into an ill-fitting standard space.
Can we integrate high-resolution histology or spatial omics with 3D anatomic volumes?
Yes. NeuroSimplicity specializes in Multi-Scalar Integration. Our platform can reconstruction 2D serial histology and spatial -omics data into coherent 3D volumes. These high-resolution micro-scale datasets are then automatically registered to macro-scale anatomic references, such as Micro-CT or Light Sheet Microscopy (LSM). This capability allows you to bridge the gap between Digital Pathology (micro) and Anatomic Imaging (macro), providing a unified molecular and structural context for your research.